From: http://www.ncbi.nlm.nih.gov/pubmed/22617750
PubMed.gov
Toxicol Lett. 2012 May 19;212(2):147-156. [Epub ahead of print]
Xu X, Deng F, Guo X, Lv P, Zhong M, Liu C, Wang A, Tzan K, Jiang SY, Lippmann M, Rajagopalan S, Qu Q, Chen LC, Sun Q.
Association of systemic inflammation with marked changes in particulate air pollution in Beijing in 2008
The authors present the background for their study: “Many studies have linked ambient fine particulate matter (aerodynamic diameters less than 2.5μm, PM(2.5)) air pollution to increased morbidity and mortality of cardiovascular diseases in the general population, but the biologic mechanisms of these associations are yet to be elucidated. In this study, we aimed to evaluate the relationship between daily variations in exposure to PM(2.5) and inflammatory responses in mice during and for 2 months after the Beijing Olympic Games.”
The results of the study were as follows: “During the Games, circulating monocyte chemoattractant protein 1 and interleukin 6 were increased significantly in the PM(2.5) exposure group, when compared with the FA control group, although there were no significant inter-group differences in tumor necrosis factor-α or interferon-γ, or in macrophages, neutrophils or lymphocytes in the spleen or thymus between these 2 groups. However, macrophages were significantly increased in the lung and visceral fat with increasing PM(2.5). After the Olympic Games, there were no significant PM(2.5)-associated differences for macrophages, neutrophils or lymphocytes in the thymus, but macrophages were significantly elevated in the lung, spleen, subcutaneous and visceral fat with increasing PM(2.5), and the numbers of macrophages were even higher after than those during the Games. Moreover, the number of neutrophils was markedly higher in the spleen for the PM(2.5)-exposed- than the FA-group.”
The authors conclude, “These data suggest that short-term increases in exposure to ambient PM(2.5) leads to increased systemic inflammatory responses, primarily macrophages and neutrophils in the lung, spleen, and visceral adipose tissue. Short-term air quality improvements were significantly associated with reduced overall inflammatory responses.”
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