Effect of Ambient Air Pollution on Pulmonary Exacerbations and Lung Function in Cystic Fibrosis

From: http://ajrccm.atsjournals.org/content/169/7/816.abstract

American Journal of Respiratory and Critical Care Medicine

Published ahead of print on January 12, 2004, doi: 10.1164/rccm.200306-779OC Am. J. Respir. Crit. Care Med. April 1, 2004 vol. 169 no. 7 816-821

Effect of Ambient Air Pollution on Pulmonary Exacerbations and Lung Function in Cystic Fibrosis

Christopher H. Goss, Stacey A. Newsom, Jonathan S. Schildcrout, Lianne Sheppard, and Joel D. Kaufman

The authors describe the results of their study: “After adjusting for confounders, a 10 μg/m3 rise in particulate matter (both with a median aerodynamic diameter of 10 μm (PM10) or less and with an aerodynamic diameter of 2.5 μm or less (PM2.5) was associated with an 8% (95% confidence interval [CI], 2–15%) and 21% (95% CI, 7–33%) increase in the odds of two or more exacerbations, respectively; a 10-ppb rise in ozone was associated with a 10% (95% CI, 3–17%) increase in odds of two or more exacerbations. For every increase in PM2.5 of 10 μg/m3, there was an associated fall in FEV1 of 24 ml (7–40) (95% CI) after adjusting for confounders. PM2.5‘s association with mortality did not achieve statistical significance (adjusted RR = 1.32 per 10 μg/m3 0.91–1.93; 95% CI).”

The authors conclude, “Annual average exposures to particulate air pollution was associated with an increased risk of pulmonary exacerbations and a decline in lung function, suggesting a role of environmental exposures on prognosis in CF [cystic fibrosis].”

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